Structure of PDB 9eu6 Chain A

Receptor sequence
>9eu6A (length=122) Species: 9606 (Homo sapiens) [Search protein sequence]
TEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLSNGKKFD
SSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEIAHLLIKPEYAYGSAGS
LPKIPSNATLFFEIELLDFKGE
3D structure
PDB9eu6 1,4-Pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile.
ChainA
Resolution1.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1H7U A Y57 G59 D68 F77 V86 W90 Y113 S118 I122 F130 Y39 G41 D50 F59 V68 W72 Y95 S100 I104 F112
External links
PDB RCSB:9eu6, PDBe:9eu6, PDBj:9eu6
PDBsum9eu6
PubMed38818693
UniProtQ13451|FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (Gene Name=FKBP5)

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