Structure of PDB 9cwn Chain A

Receptor sequence
>9cwnA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
SADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMM
GEDKIKFKHITEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLD
LNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQ
DNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTE
TDMSLHPLLQEIYKDLY
3D structure
PDB9cwn NRIP1_133 / RIP140 SxxLxxLL motif coregulator peptide with agonist GW1929 and PPARg LBD
ChainA
Resolution2.7 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A T325 K329 P495 L496 E499 T87 K91 P257 L258 E261
BS02 EDK A F310 G312 C313 Q314 S317 H351 L358 I369 M376 F391 M392 H477 L497 Y501 F72 G74 C75 Q76 S79 H113 L120 I131 M138 F153 M154 H239 L259 Y263
External links
PDB RCSB:9cwn, PDBe:9cwn, PDBj:9cwn
PDBsum9cwn
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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