Structure of PDB 9cuo Chain A

Receptor sequence
>9cuoA (length=96) Species: 9606 (Homo sapiens) [Search protein sequence]
SPTSLCCKQCQETEITTKNEIFSLSVHETLTVYKACNLNLIGRPSTEHSW
FPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTI
3D structure
PDB9cuo Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases.
ChainA
Resolution1.6 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C323 C326 C391 C394 C7 C10 C61 C64
BS02 A1A0J A E377 H378 S379 W380 W386 W400 F402 E47 H48 S49 W50 W56 W70 F72
External links
PDB RCSB:9cuo, PDBe:9cuo, PDBj:9cuo
PDBsum9cuo
PubMed39151120
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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