Structure of PDB 9cts Chain A

Receptor sequence
>9ctsA (length=376) Species: 9606 (Homo sapiens) [Search protein sequence]
TITYTSQVANARLGSFSRLLLCWRGSIYKLLYGEFLIFLLCYYIIRFIYR
LALTEEQQLMFEKLTLYCDSYIQLIPISFVLGFYVTLVVTRWWNQYENLP
WPDRLMSLVSGFVEGKDEQGRLLRRTLIRYANLGNVLILRSVSTAVYKRF
PSAQHLVQAGFMTPAEHKQLEKLSLPHNMFWVPWVWFANLSMKAWLGGRI
RDPILLQSLLNEMNTLRTQCGHLYAYDWISIPLVYTQVVTVAVYSFFLTC
LVGRQFLNPAKAYPGHELDLVVPVFTFLQFFFYVGWLKVAEQLINPFGED
DDDFETNWIVDRNLQVSLLAVDEMHQDLPRMEPDMYWNKPEPQPPYTAAS
AQFRRASFMGSTFNISLNKEEMEFQP
3D structure
PDB9cts GAD65 tunes the functions of Best1 as a GABA receptor and a neurotransmitter conducting channel.
ChainA
Resolution2.45 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ABU A Y68 Y72 Y67 Y71
BS02 CA A Q293 N296 D301 D304 Q292 N295 D300 D303
BS03 ABU A R255 F257 H267 T277 R254 F256 H266 T276
External links
PDB RCSB:9cts, PDBe:9cts, PDBj:9cts
PDBsum9cts
PubMed39277606
UniProtO76090|BEST1_HUMAN Bestrophin-1 (Gene Name=BEST1)

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