Structure of PDB 9ctq Chain A

Receptor sequence

>9ctqA (length=376) Species: 9606 (Homo sapiens) [Search protein sequence]

TITYTSQVANARLGSFSRLLLCWRGSIYKLLYGEFLIFLLCYYIIRFIYR
LALTEEQQLMFEKLTLYCDSYIQLIPISFVLGFYVTLVVTRWWNQYENLP
WPDRLMSLVSGFVEGKDEQGRLLRRTLIRYANLGNVLILRSVSTAVYKRF
PSAQHLVQAGFMTPAEHKQLEKLSLPHNMFWVPWVWFANLSMKAWLGGRI
RDPILLQSLLNEMNTLRTQCGHLYAYDWISIPLVYTQVVTVAVYSFFLTC
LVGRQFLNPAKAYPGHELDLVVPVFTFLQFFFYVGWLKVAEQLINPFGED
DDDFETNWIVDRNLQVSLLAVDEMHQDLPRMEPDMYWNKPEPQPPYTAAS
AQFRRASFMGSTFNISLNKEEMEFQP

3D structure

PDB

9ctq GAD65 tunes the functions of Best1 as a GABA receptor and a neurotransmitter conducting channel.

Chain

Resolution

2.41 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	Q293 N296 D301 D304	Q292 N295 D300 D303
BS02	ABU	A	R255 F257 P274 F276 T277	R254 F256 P273 F275 T276

External links

PDB	RCSB:9ctq, PDBe:9ctq, PDBj:9ctq
PDBsum	9ctq
PubMed	39277606
UniProt	O76090\|BEST1_HUMAN Bestrophin-1 (Gene Name=BEST1)

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