Structure of PDB 9ciq Chain A

Receptor sequence

>9ciqA (length=427) Species: 9606 (Homo sapiens) [Search protein sequence]

MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAV
SYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVM
EIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGL
PQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNTSGIQTEWSPPLTMLFLCATKFSAS

3D structure

PDB

9ciq DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta.

Chain

Resolution

2.8 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	Q38 Y39 W42 S62 W64 K86 P316 K317 T318 I319 G320 C321 S322 K323 N324 P326 G327 R351	Q38 Y39 W42 S62 W64 K86 P311 K312 T313 I314 G315 C316 S317 K318 N319 P321 G322 R346
BS02	dna	A	S113 S257 G259 G260 K261 L262 R377 R382 C384	S113 S252 G254 G255 K256 L257 R372 R377 C379
BS03	A1ANT	A	M14 C16 R55 R61 D115 K231	M14 C16 R55 R61 D115 K226
BS04	CA	A	D13 M14 D115	D13 M14 D115
BS05	CA	A	D13 D115 E116	D13 D115 E116

External links

PDB	RCSB:9ciq, PDBe:9ciq, PDBj:9ciq
PDBsum	9ciq
PubMed	39259676
UniProt	Q9Y253\|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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