Structure of PDB 9cih Chain A

Receptor sequence

>9cihA (length=424) Species: 9606 (Homo sapiens) [Search protein sequence]

ATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAVS
YEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVME
IMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIEGLP
QGVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERET
GFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSL
GGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEHD
PVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRND
NDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCNT
SGIQTEWSPPLTMLFLCATKFSAS

3D structure

PDB

9cih DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta.

Chain

Resolution

2.15 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	Q38 Y39 W42 K86 R93 K311 R313 P316 K317 T318 G320 C321 S322 K323 N324 P326 K328 L378	Q37 Y38 W41 K85 R92 K303 R305 P308 K309 T310 G312 C313 S314 K315 N316 P318 K320 L370
BS02	dna	A	A112 S113 E116 K224 R256 S257 G259 K261 L262 R377 L381 R382 C384	A111 S112 E115 K216 R248 S249 G251 K253 L254 R369 L373 R374 C376
BS03	0KX	A	D13 M14 D15 C16 F17 F18 Y52 R55 R61 D115 K231	D12 M13 D14 C15 F16 F17 Y51 R54 R60 D114 K223
BS04	MG	A	D13 D115 E116	D12 D114 E115
BS05	MG	A	D13 M14 D115	D12 M13 D114

External links

PDB	RCSB:9cih, PDBe:9cih, PDBj:9cih
PDBsum	9cih
PubMed	39259676
UniProt	Q9Y253\|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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