Structure of PDB 9chw Chain A

Receptor sequence

>9chwA (length=431) Species: 9606 (Homo sapiens) [Search protein sequence]

GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPTTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMR
AAIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMP
IRKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAM
CRGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEER
LTKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFT
VIKNCNTSGIQTEWSPPLTMLFLCATKFSAS

3D structure

PDB

9chw DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta.

Chain

Resolution

2.16 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	Q38 Y39 W42 S62 K86 L89 R93 K311 R313 P316 K317 T318 G320 S322 K323 N324 P326 G327	Q41 Y42 W45 S65 K89 L92 R96 K310 R312 P315 K316 T317 G319 S321 K322 N323 P325 G326
BS02	dna	A	S113 E116 S257 G259 K261 L262 R377 L381 R382	S116 E119 S256 G258 K260 L261 R376 L380 R381
BS03	DZ4	A	D13 M14 D15 C16 F17 F18 Y52 R55 R61 D115 K231	D16 M17 D18 C19 F20 F21 Y55 R58 R64 D118 K230
BS04	MG	A	D13 M14 D115	D16 M17 D118
BS05	MG	A	D13 D115 E116	D16 D118 E119

External links

PDB	RCSB:9chw, PDBe:9chw, PDBj:9chw
PDBsum	9chw
PubMed	39259676
UniProt	Q9Y253\|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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