Structure of PDB 9cd5 Chain A

Receptor sequence
>9cd5A (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
LPEDPRWELPRDRLVLGKPLGEGAGQVVLAEAIGLDKDKPNRVTKVAVKM
LKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS
KGNLREYLQARRPPGEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAAR
NVLVTEDNVMKIADFGLIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV
WSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMM
RDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ
3D structure
PDB9cd5 Discovery of TYRA-300: First Oral Selective FGFR3 Inhibitor for the Treatment of Urothelial Cancers and Achondroplasia.
ChainA
Resolution2.939 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AV2 A L484 G485 V492 A512 Y563 A564 G567 N568 R627 L630 L20 G21 V27 A47 Y98 A99 G102 N103 R150 L153
External links
PDB RCSB:9cd5, PDBe:9cd5, PDBj:9cd5
PDBsum9cd5
PubMed39258897
UniProtP11362|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

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