Structure of PDB 9cbt Chain A

Receptor sequence

>9cbtA (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]

KLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQY
DLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGL
LLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRAD
VMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTS
LEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVE
SLVELLGWTEEMRDLVQRET

3D structure

PDB

9cbt Crystal structure of human sirtuin 3 fragment (residues 118-399) bound to intermediates from reaction with NAD and inhibitor NH6-10

Chain

Resolution

1.95 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	A	C256 C259 C280 C283	C135 C138 C159 C162
BS02	5IA	A	G145 A146 G147 T150 I154 D156 F157 R158 F180 L199 Q228 I230 D231 H248 V292 F293 F294 E296 P297 L298 G319 T320 S321 V324 E325 N344 R345 D365 V366	G24 A25 G26 T29 I33 D35 F36 R37 F59 L78 Q107 I109 D110 H127 V171 F172 F173 E175 P176 L177 G198 T199 S200 V203 E204 N223 R224 D244 V245
BS03	5I7	A	F186 E296	F65 E175

External links

PDB	RCSB:9cbt, PDBe:9cbt, PDBj:9cbt
PDBsum	9cbt
PubMed
UniProt	Q9NTG7\|SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Gene Name=SIRT3)

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