Structure of PDB 9ca0 Chain A

Receptor sequence

>9ca0A (length=612) Species: 9606 (Homo sapiens)

VMKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQP
VRFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMV
KFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNKAHGGEKTVFR
ARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKY
FQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNT
DKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPL
ALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFD
LKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGDHPPITPMKSATEA
ELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLS
PGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAEL
ITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYY
KIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDS
IAGMDELMEVSF

3D structure

• PDB: 9ca0 Structural Insights into human Topoisomerase 3-beta DNA and RNA catalytic cycles and topo-gate dynamics
• Chain: A
• Resolution: 3.48 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	E9 H60 T63 N71 W73 R181 D185 L186 G189 C190 T193 R194 S213 F214 C217 Q218 Y336 T510 S513 H517 R524 R561	E10 H61 T64 N72 W74 R182 D186 L187 G190 C191 T194 R195 S214 F215 C218 Q219 Y337 T511 S514 H518 R525 R562
BS02	dna	A	A35 C58 K95 L96 E326 Y336	A36 C59 K96 L97 E327 Y337
BS03	MN	A	D117 D119	D118 D120

External links

• PDB: RCSB:9ca0, PDBe:9ca0, PDBj:9ca0
• PDBsum: 9ca0
• UniProt: O95985|TOP3B_HUMAN DNA topoisomerase 3-beta-1 (Gene Name=TOP3B)