Structure of PDB 9c9y Chain A

Receptor sequence
>9c9yA (length=612) Species: 9606 (Homo sapiens) [Search protein sequence]
VMKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQP
VRFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMV
KFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNKAHGGEKTVFR
ARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKY
FQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNT
DKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPL
ALNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISFPRTETTHYPENFD
LKGSLRQQANHPYWADTVKRLLAEGINRPRKGHDAGDHPPITPMKSATEA
ELGGDAWRLYEYITRHFIATVSHDCKYLQSTISFRIGPELFTCSGKTVLS
PGFTEVMPWQSVPLEESLPTCQRGDAFPVGEVKMLEKQTNPPDYLTEAEL
ITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNLGIVLVHGYY
KIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDS
IAGMDELMEVSF
3D structure
PDB9c9y Structural Insights into human Topoisomerase 3-beta DNA and RNA catalytic cycles and topo-gate dynamics
ChainA
Resolution3.35 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A K10 G59 H60 W73 E121 D185 L186 C190 S213 P216 C217 Q218 E326 F336 S513 H517 R524 R561 K11 G60 H61 W74 E122 D186 L187 C191 S214 P217 C218 Q219 E327 F337 S514 H518 R525 R562
BS02 MN A E9 D117 E10 D118
BS03 MN A E340 D511 E341 D512
External links
PDB RCSB:9c9y, PDBe:9c9y, PDBj:9c9y
PDBsum9c9y
PubMed
UniProtO95985|TOP3B_HUMAN DNA topoisomerase 3-beta-1 (Gene Name=TOP3B)

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