Structure of PDB 9c8u Chain A

Receptor sequence

>9c8uA (length=475) Species: 9606 (Homo sapiens) [Search protein sequence]

EYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHIL
TSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFM
VEDPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHRKCNYS
FHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKPNIE
PPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESS
IINHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRC
KAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKK
HLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYM
CSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFA
KRAIQTGEELFFDYRYSQADALKYV

3D structure

PDB

9c8u Structural basis for inactivation of PRC2 by G-quadruplex RNA.

Chain

Resolution

3.1 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ZN	A	C528 H530 C535 C539	C261 H263 C268 C272
BS02	ZN	A	C528 C541 C552	C261 C274 C285
BS03	ZN	A	C535 C548 C554 C558	C268 C281 C287 C291
BS04	ZN	A	C565 C567 C571 C576	C298 C300 C304 C309
BS05	ZN	A	C571 C585 C593 C606	C304 C318 C326 C339
BS06	ZN	A	C565 C578 C585 C590	C298 C311 C318 C323
BS07	ZN	A	C286 C289 C294 H297	C133 C136 C141 H144

External links

PDB	RCSB:9c8u, PDBe:9c8u, PDBj:9c8u
PDBsum	9c8u
PubMed
UniProt	Q15910\|EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 (Gene Name=EZH2)

[Back to BioLiP]