Structure of PDB 9c4o Chain A

Receptor sequence

>9c4oA (length=661) Species: 679895 (Escherichia coli BW25113)

SELDTPAAVSVVDGEEMRLATPRINLSESLTGVPGLQVQNRQNYAQDLQL
SIRGFGSRSTYGIRGIRLYVDGIPATMPDGQGQTSNIDLSSVQNVEVLRG
PFSALYGNASGGVMNVTTQTGQQPPTIEASSYYGSFGSWRYGLKATGATG
DGTQPGDVDYTVSTTRFTTHGYRDHSGAQKNLANAKLGVRIDEASKLSLI
FNSVDIKADDPGGLTKAEWKANPQQAPRAEQYDTRKTIKQTQAGLRYERS
LSSRDDMSVMMYAGERETTQYQSIPMAPQLNPSHAGGVITLQRHYQGIDS
RWTHRGELGVPVTFTTGLNYENMSENRKGYNNFRLNSGMPEYGQKGELRR
DERNLMWNIDPYLQTQWQLSEKLSLDAGVRYSSVWFDSNDHYVTPGNGDD
SGDASYHKWLPAGSLKYAMTDAWNIYLAAGRGFETPTINELSYRADGQSG
MNLGLKPSTNDTIEIGSKTRIGDGLLSLALFQTDTDDEIVVDSSSGGRTT
YKNAGKTRRQGAELAWDQRFAGDFRVNASWTWLDATYRSNVCNEQDCNGN
RMPGIARNMGFASIGYVPEDGWYAGTEARYMGDIMADDENTAKAPSYTLV
GLFTGYKYNYHNLTVDLFGRVDNLFDKEYVGSVIVNESNGRYYEPSPGRN
YGVGMNIAWRF

3D structure

• PDB: 9c4o High-affinity PQQ import is widespread in Gram-negative bacteria.
• Chain: A
• Resolution: 1.99 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	D428 Y430 N435 G436 D438	D390 Y392 N397 G398 D400
BS02	PQQ	A	Q84 Y99 Q121 K274 I276 R304 T306 Q308 Q310 I327 L329 R365 N477 Y481 R536	Q46 Y61 Q83 K236 I238 R266 T268 Q270 Q272 I289 L291 R327 N439 Y443 R498

Gene Ontology

Molecular Function

• GO:0015344 siderophore uptake transmembrane transporter activity

Biological Process

• GO:0030003 intracellular monoatomic cation homeostasis
• GO:0033214 siderophore-dependent iron import into cell
• GO:0044718 siderophore transmembrane transport

Cellular Component

• GO:0009279 cell outer membrane
• GO:0016020 membrane
• GO:1902495 transmembrane transporter complex

External links

• PDB: RCSB:9c4o, PDBe:9c4o, PDBj:9c4o
• PDBsum: 9c4o
• UniProt: P76115|PQQU_ECOLI Pyrroloquinoline quinone transporter (Gene Name=pqqU)