Structure of PDB 9c1w Chain A

Receptor sequence
>9c1wA (length=388) Species: 9606 (Homo sapiens) [Search protein sequence]
EVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPQTLPPLNNFS
VAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMV
ANSLKQRAAAEDKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKIL
RKEVIIAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELF
FHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGH
IKITDFGLCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYN
QDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKE
VMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFD
3D structure
PDB9c1w Mutant-selective AKT1 inhibitors via lysine targeting and neo-zinc chelation
ChainA
Resolution2.0 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XOO A E17 Y18 N53 Q79 W80 T207 L212 T213 V271 Y273 R274 D293 E15 Y16 N47 Q73 W74 T169 L174 T175 V233 Y235 R236 D255
External links
PDB RCSB:9c1w, PDBe:9c1w, PDBj:9c1w
PDBsum9c1w
PubMed
UniProtP31751|AKT2_HUMAN RAC-beta serine/threonine-protein kinase (Gene Name=AKT2)

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