Structure of PDB 9c1r Chain A

Receptor sequence
>9c1rA (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
MQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGT
LLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGIC
LRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLA
SKKFVHRDLAARNCMLDEKFTVKVADFGPVKWMALESLQTQKFTTKSDVW
SFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVML
KCWHPKAEMRPSFSELVSRISAIFSTFIGEHHHHH
3D structure
PDB9c1r Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy.
ChainA
Resolution1.59 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1ATS A I1084 G1085 V1092 A1108 K1110 E1127 M1131 F1134 M1160 F1200 H1202 M1211 V1220 A1221 D1222 F1223 I38 G39 V46 A62 K64 E81 M85 F88 M114 F154 H156 M165 V174 A175 D176 F177
External links
PDB RCSB:9c1r, PDBe:9c1r, PDBj:9c1r
PDBsum9c1r
PubMed39088797
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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