Structure of PDB 9bs4 Chain A

Receptor sequence

>9bs4A (length=627) Species: 9606 (Homo sapiens)

DPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVET
LSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLALGVGDGVLLKAVAQA
TGRQLESVRAEAAEKGDVGLVAENSRPPPPLTASGVFSKFRDIARLTGSA
STAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVS
LTPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIP
VLLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEYK
YDGQRAQIHALEGGEVKIFSRNQADNTGKYPDIISRIPKIKLPSVTSFIL
DTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGE
SLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDS
CEGLMVKTLDVDATYEIAKRSHNWLKLKKDYDTLDLVVIGAYLGRGKRAG
RYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPY
VRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFP
RFIRVREDKQPEQATTSAQVACLYRKQ

3D structure

• PDB: 9bs4 Structures of LIG1 uncover the mechanism of sugar discrimination against 5'-RNA-DNA junctions during ribonucleotide excision repair.
• Chain: A
• Resolution: 2.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	G348 V349 G350 G352 V353 G571 Q572 S588 R589 N590 F635	G87 V88 G89 G91 V92 G303 Q304 S320 R321 N322 F367
BS02	dna	A	A304 R589 R738 K744 T798 G799 F872	A43 R321 R470 K476 T525 G526 F599
BS03	dna	A	R305 T415 G416 A418 S419 T420 R451 G453 A455 Q457 S458 Q636 T639 T640 K642 R643	R44 T147 G148 A150 S151 T152 R183 G185 A187 Q189 S190 Q368 T371 T372 K374 R375
BS04	AMP	A	E566 Y567 K568 Y569 E621 F660 E720 M723 K725 K744 K746	E298 Y299 K300 Y301 E353 F392 E452 M455 K457 K476 K478

External links

• PDB: RCSB:9bs4, PDBe:9bs4, PDBj:9bs4
• PDBsum: 9bs4
• PubMed: 39159820
• UniProt: P18858|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)