Structure of PDB 9bit Chain A

Receptor sequence
>9bitA (length=472) Species: 10116 (Rattus norvegicus) [Search protein sequence]
FGSSYPVSIAFIVVNEFCERFSYYGMKAVLTLYFLYFLHWNEDTSTSVYH
AFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVFKSLGAIPILG
GKMLHTILSLVGLSLIALGTGGIKPCVAAFGGDQFEEEHAEARTRYFSVF
YLAINAGSLISTFITPMLRGDVKCFGQDCYALAFGVPGLLMVLALVVFAM
GSKMYRKPPPEGNIVAQVIKCIWFALCNRFRNRSGDLPKRQHWLDWAAEK
YPKHLIADVKALTRVLFLYIPLPMFWALLDQQGSRWTLQANKMNGDLGFF
VLQPDQMQVLNPFLVLIFIPLFDLVIYRLISKCRINFSSLRKMAVGMILA
CLAFAVAALVETKINGMIHPEDIPVNKLSIAWQLPQYVLVTAAEVMFSVT
GLEFSYSQAPSSMKSVLQAAWLLTVAVGNIIVLVVAQFSGLAQWAEFVLF
SCLLLVVCLIFSVMAYYYVPLK
3D structure
PDB9bit Structural basis for antibiotic transport and inhibition in the mammalian proton-coupled peptide transporter, PepT2
ChainA
Resolution3.1 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CXN A E53 Y61 Y94 K161 I191 W313 E16 Y24 Y57 K124 I154 W276
Gene Ontology
Molecular Function
GO:0015293 symporter activity
GO:0015333 peptide:proton symporter activity
GO:0015334 high-affinity oligopeptide transmembrane transporter activity
GO:0042937 tripeptide transmembrane transporter activity
GO:0071916 dipeptide transmembrane transporter activity
Biological Process
GO:0006857 oligopeptide transport
GO:0015031 protein transport
GO:0015833 peptide transport
GO:0015835 peptidoglycan transport
GO:0042908 xenobiotic transport
GO:0042938 dipeptide transport
GO:0045087 innate immune response
GO:0070293 renal absorption
GO:0070424 regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0072237 metanephric proximal tubule development
GO:0140206 dipeptide import across plasma membrane
GO:0140207 tripeptide import across plasma membrane
GO:0140367 antibacterial innate immune response
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0030670 phagocytic vesicle membrane
GO:0031410 cytoplasmic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:9bit, PDBe:9bit, PDBj:9bit
PDBsum9bit
PubMed
UniProtQ63424|S15A2_RAT Solute carrier family 15 member 2 (Gene Name=Slc15a2)

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