Structure of PDB 9bh9 Chain A

Receptor sequence
>9bh9A (length=787) Species: 9606 (Homo sapiens) [Search protein sequence]
KLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPT
SAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIK
VDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDE
LHMLGDSHRGYLLELLLTKICYITRKSASSNAVQIVGMSATLPNLELVAS
WLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHV
VSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQACPPVILEQ
KELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQ
GLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRK
GVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRA
ILEIIVGGVASTSQDMHTYAACTFLAASMKVQLGAIEACVMWLLENEFIQ
STEAGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHIL
YLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGK
VVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSL
QQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSL
LNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEE
AVEERRNMRTIWKGLTEREAAALIVEEARMILQQDLV
3D structure
PDB9bh9 Human polymerase theta helicase positions DNA microhomologies for double-strand break repair
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A F146 V147 G173 T190 E192 R193 K347 A418 G465 S622 V757 Y758 G760 M761 F79 V80 G106 T123 E125 R126 K271 A334 G381 S521 V656 Y657 G659 M660
BS02 dna A R179 H180 R112 H113
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:9bh9, PDBe:9bh9, PDBj:9bh9
PDBsum9bh9
PubMed
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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