Structure of PDB 9bg1 Chain A

Receptor sequence
>9bg1A (length=169) Species: 9606 (Homo sapiens) [Search protein sequence]
SMTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKHKE
3D structure
PDB9bg1 Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers.
ChainA
Resolution1.51 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP A G13 G15 K16 S17 A18 F28 D30 Y32 T35 G60 N116 K117 D119 L120 S145 A146 G14 G16 K17 S18 A19 F29 D31 Y33 T36 G61 N117 K118 D120 L121 S146 A147
BS02 MG A S17 T35 S18 T36
BS03 A1AOH A P34 I36 E37 A59 Q61 Y64 M67 Y71 P35 I37 E38 A60 Q62 Y65 M68 Y72
External links
PDB RCSB:9bg1, PDBe:9bg1, PDBj:9bg1
PDBsum9bg1
PubMed
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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