Structure of PDB 9bfb Chain A

Receptor sequence
>9bfbA (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVPTPQQLQAFK
NEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFE
MIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLAT
VKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYEL
MTGQLPYSNINNRDQIIAMVGAGALSPDLSKVRSNCPKAMKRLMAECLKK
KRDERPLFPQILASIELLARSL
3D structure
PDB9bfb Identification of the Clinical Candidate PF-07284890 ( ARRY-461 ), a Highly Potent and Brain Penetrant BRAF Inhibitor for the Treatment of Cancer.
ChainA
Resolution1.92 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AN9 A V471 A481 K483 L514 T529 W531 C532 F583 G593 D594 F595 G596 V24 A34 K36 L65 T80 W82 C83 F134 G144 D145 F146 G147
External links
PDB RCSB:9bfb, PDBe:9bfb, PDBj:9bfb
PDBsum9bfb
PubMed39077892
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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