Structure of PDB 9b8y Chain A

Receptor sequence
>9b8yA (length=978) Species: 9606 (Homo sapiens) [Search protein sequence]
EQSWIPKIFKKKTCTTFIVTLCQCGRPRTAHPAVATVWDSDAHTTEKPTD
AYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLG
GSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDH
QMASKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDY
NYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLL
IDGDEKMLTRIENATQAQLPCLLVAGSGGAADCLAETLEDQGEARDRIRR
FFPKGDLEVLQAQVERIMTRKELLTVYSSEDGSEEFETIVLKALVKACGS
SEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDR
PEFVRLLISHGLSLGHFLTPMRLAQLYSAAPSNSLIRNLLDQAPPDVGHV
LRMLLGKMAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRV
MARLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPL
WGDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFF
CPPLIYTRLITFRRCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLV
DFQPAPPGSLELLLYFWAFTLLCEELRQGLSGSLSQRLRLYLADSWNQCD
LVALTCFLLGVGCRLTPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGP
KIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFY
RPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANW
LVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIRE
FHSRPALAPPFIVISHLRLLKEAERKLLTWESVHKENFLLARARDKRESD
SERLKRTSQKVDLALKQLGHIREYEQRL
3D structure
PDB9b8y Physiological Temperature Drives TRPM4 Ligand Recognition and Gating
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E828 Q831 N865 D868 E675 Q678 N697 D700
BS02 CA A D270 A392 D395 E396 D243 A355 D358 E359
BS03 DVT A R601 K613 K925 R503 K515 K757
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005227 calcium-activated cation channel activity
GO:0005262 calcium channel activity
GO:0005272 sodium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0099604 ligand-gated calcium channel activity
Biological Process
GO:0002250 adaptive immune response
GO:0002407 dendritic cell chemotaxis
GO:0002724 regulation of T cell cytokine production
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008284 positive regulation of cell population proliferation
GO:0010460 positive regulation of heart rate
GO:0016925 protein sumoylation
GO:0019722 calcium-mediated signaling
GO:0030502 negative regulation of bone mineralization
GO:0034220 monoatomic ion transmembrane transport
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045600 positive regulation of fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045907 positive regulation of vasoconstriction
GO:0051289 protein homotetramerization
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0071318 cellular response to ATP
GO:0086045 membrane depolarization during AV node cell action potential
GO:0086047 membrane depolarization during Purkinje myocyte cell action potential
GO:0086048 membrane depolarization during bundle of His cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0098662 inorganic cation transmembrane transport
GO:0098719 sodium ion import across plasma membrane
GO:0098911 regulation of ventricular cardiac muscle cell action potential
GO:1903949 positive regulation of atrial cardiac muscle cell action potential
GO:1904179 positive regulation of adipose tissue development
GO:1904199 positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
Cellular Component
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034706 sodium channel complex
GO:0043025 neuronal cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:9b8y, PDBe:9b8y, PDBj:9b8y
PDBsum9b8y
PubMed38750366
UniProtQ8TD43|TRPM4_HUMAN Transient receptor potential cation channel subfamily M member 4 (Gene Name=TRPM4)

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