Structure of PDB 9b6h Chain A

Receptor sequence
>9b6hA (length=934) Species: 10090 (Mus musculus) [Search protein sequence]
DLVNFIQANFKDAFGDIQFGKYLRLSCDTDSETLYELLTQHWHLKTPNLV
ISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEV
VRDNTISENIVAIGIAAWGMVSNRDTLFSAQYIMLYILDNNHTHLLLVDN
GCHGHPTVEAKLRNQLEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKA
INTSVKSKIPCVVVEGSGQIADVIASLVTSSMVKEKLVRFLPRTVSRLPE
EEIESWIKWLKEILESSHLLTVIKMEEAGDEIVSNAISYALYKAFSTNEQ
DKDNWNGQLKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIKDRP
KFVRLFLENGLNLQKFLTNEVLTELFSTHFSTLVYRNLQIAKNSYNDALL
TFVWKLVANFRRSTRHPLQALFIWAILQNKKELSKVIWEQTKGCTLAALG
ASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSNDEDLAEQL
LVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNW
KIILCLFIIPLVGCGLVSFRKKKLLWYYVAFFTSPFVVFSWNVVFYIAFL
LLFAYVLLMDFHSVPHTPELILYALVFVLFCDEVRQWYMNGVNYFTDLWN
VMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTV
SRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWI
FRSVIYEPYLAMFGQVPSDVDSTTYDFSHCTFSGNESKPLCVELDEHNLP
RFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRY
FLVQEYCNRLNIPFPFVVFAYFYMVVKKDNETLAWEGVMKENYLVKINTK
ANDNSEEMRHRFRQLDSKLNDLKSLLKEIANNIK
3D structure
PDB9b6h Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
ChainA
Resolution2.76 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 A I746 F847 S850 I597 F698 S701
BS02 Y01 A S739 V849 S590 V700
BS03 ULO A N741 Y745 M801 D802 F839 R842 I846 Y1005 F1013 N592 Y596 M652 D653 F690 R693 I697 Y856 F864
BS04 T14 A W877 S966 W728 S817
BS05 Y01 A E953 I957 E804 I808
External links
PDB RCSB:9b6h, PDBe:9b6h, PDBj:9b6h
PDBsum9b6h
PubMed39093967
UniProtQ8R4D5|TRPM8_MOUSE Transient receptor potential cation channel subfamily M member 8 (Gene Name=Trpm8)

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