Structure of PDB 9b1q Chain A

Receptor sequence

>9b1qA (length=345) Species: 9606 (Homo sapiens) [Search protein sequence]

LIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWE
LDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALD
FNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEEN
ELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFI
RIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRAL
QGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSS
GYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLEH

3D structure

PDB

9b1q Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.

Chain

Resolution

2.624 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEM	A	F72 H76 Y79 S151 G152 F153 F158 R159 Y175 W324 H328 M331 V332 L336 Y350	F33 H37 Y40 S112 G113 F114 F119 R120 Y136 W285 H289 M292 V293 L297 Y304
BS02	A1AH8	A	F72 H76 A150 S151 G152	F33 H37 A111 S112 G113
BS03	ZIQ	A	R103 W208 R211 T212 P213 F304 P307	R64 W169 R172 T173 P174 F265 P268
BS04	A1AH8	A	Y42 Y45	Y3 Y6

External links

PDB	RCSB:9b1q, PDBe:9b1q, PDBj:9b1q
PDBsum	9b1q
PubMed	39106326
UniProt	P48775\|T23O_HUMAN Tryptophan 2,3-dioxygenase (Gene Name=TDO2)

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