Structure of PDB 9b17 Chain A

Receptor sequence

>9b17A (length=346) Species: 9606 (Homo sapiens) [Search protein sequence]

GLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILW
ELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTAL
DFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEE
NELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEF
IRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRA
LQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGS
SGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLEH

3D structure

PDB

9b17 Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.

Chain

Resolution

2.65 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEM	A	F72 H76 Y79 F140 S151 G152 F153 F158 R159 Y175 W324 H328 M331 V332 L336 Y350 L351	F34 H38 Y41 F102 S113 G114 F115 F120 R121 Y137 W286 H290 M293 V294 L298 Y305 L306
BS02	A1AH9	A	F72 H76 R144 A150 S151 G152	F34 H38 R106 A112 S113 G114
BS03	ZIQ	A	R103 W208 R211 P213 F304 P307	R65 W170 R173 P175 F266 P269

External links

PDB	RCSB:9b17, PDBe:9b17, PDBj:9b17
PDBsum	9b17
PubMed	39106326
UniProt	P48775\|T23O_HUMAN Tryptophan 2,3-dioxygenase (Gene Name=TDO2)

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