Structure of PDB 9ayl Chain A

Receptor sequence

>9aylA (length=1055) Species: 9606 (Homo sapiens)

LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA
FFAVEMVIKMVALGLDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRV
LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA
GLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCS
HIPGRRINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWV
DIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETRIVDSK
YFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLK
LLACGPLGYIRNPYNIFDGIIVVISVWEIVGQSVLRTFRLLRVLKLVRFL
PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSPDRKNF
DSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLF
NLLVAILVEGFQRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDID
PGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDG
LLVLVSLVDIVVAMAGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVET
LISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQ
CRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQ
PVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHSPTRRSIH
SLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFV
FEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINP
TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFF
IYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWN
GIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMK
HLEES

3D structure

• PDB: 9ayl Structural basis for human Ca v 3.2 inhibition by selective antagonists.
• Chain: A
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	A1AHK	A	F408 F1550 F1756 S1805 T1806 Q1848 L1851 V1852	F277 F778 F945 S994 T995 Q1037 L1040 V1041
BS02	CA	A	E378 D1504	E247 D732
BS03	LPE	A	F393 F396 M1757 M1796 F1798	F262 F265 M946 M985 F987
BS04	Y01	A	A1312 R1315 F1761	A543 R546 F950
BS05	JL3	A	F238 F241 G365 Y366 S989 W990	F135 F138 G234 Y235 S482 W483
BS06	Y01	A	N363 H1638	N232 H827
BS07	JL3	A	S986 T987 S988 W990	S479 T480 S481 W483
BS08	JL3	A	V1546 T1806 Q1848	V774 T995 Q1037
BS09	JL3	A	T885 N1528 M1531	T387 N756 M759
BS10	Y01	A	Y814 N1489 L1490 G1491	Y321 N717 L718 G719
BS11	Y01	A	G1491 Q1492 P1837	G719 Q720 P1026

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005245 voltage-gated calcium channel activity
• GO:0005261 monoatomic cation channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0005891 voltage-gated calcium channel complex
• GO:0016020 membrane

External links

• PDB: RCSB:9ayl, PDBe:9ayl, PDBj:9ayl
• PDBsum: 9ayl
• PubMed: 38605177
• UniProt: O95180|CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H (Gene Name=CACNA1H)