Structure of PDB 9ayk Chain A

Receptor sequence

>9aykA (length=1056) Species: 9606 (Homo sapiens)

LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA
FFAVEMVIKMVALGLDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRV
LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA
GLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCS
HIPGRRINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWV
DIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETRIVDSK
YFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLK
LLACGPLGYIRNPYNIFDGIIVVISVWEIVGQSVLRTFRLLRVLKLVRFL
PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSPDRKNF
DSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLF
NLLVAILVEGFQARFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDI
DPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLD
GLLVLVSLVDIVVAMAGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVE
TLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKA
QCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQ
QPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHSPTRRSI
HSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVF
VFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPIN
PTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLF
FIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNW
NGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLM
KHLEES

3D structure

• PDB: 9ayk Structural basis for human Ca v 3.2 inhibition by selective antagonists.
• Chain: A
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	A1AHJ	A	L922 F968 L971 G1002 N1003 F1007 K1503	L424 F461 L464 G495 N496 F500 K732
BS02	CA	A	E378 E974 D1504	E247 E467 D733
BS03	LPE	A	F393 G1795 M1796 F1798 F1802	F262 G985 M986 F988 F992
BS04	Y01	A	A1312 R1315 D1317 F1761 N1793	A544 R547 D549 F951 N983
BS05	JL3	A	W368 S989 W990	W237 S482 W483
BS06	Y01	A	N363 S1635 H1638	N232 S825 H828
BS07	JL3	A	S986 T987 S988	S479 T480 S481
BS08	JL3	A	K1503 V1546 M1549 T1806 L1845 Q1848	K732 V775 M778 T996 L1035 Q1038
BS09	JL3	A	T885 M1531	T387 M760
BS10	Y01	A	L808 G811 V812 Y814 I1442 L1490	L315 G318 V319 Y321 I671 L719
BS11	Y01	A	G1491 M1495	G720 M724

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005245 voltage-gated calcium channel activity
• GO:0005261 monoatomic cation channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0005891 voltage-gated calcium channel complex
• GO:0016020 membrane

External links

• PDB: RCSB:9ayk, PDBe:9ayk, PDBj:9ayk
• PDBsum: 9ayk
• PubMed: 38605177
• UniProt: O95180|CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H (Gene Name=CACNA1H)