Structure of PDB 9ayh Chain A

Receptor sequence

>9ayhA (length=1056) Species: 9606 (Homo sapiens)

LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA
FFAVEMVIKMVALGLDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRV
LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA
GLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCS
HIPGRRINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWV
DIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETRIVDSK
YFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLK
LLACGPLGYIRNPYNIFDGIIVVISVWEIVGQSVLRTFRLLRVLKLVRFL
PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSPDRKNF
DSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLF
NLLVAILVEGFQARFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDI
DPGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLD
GLLVLVSLVDIVVAMAGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVE
TLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKA
QCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQ
QPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHSPTRRSI
HSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVF
VFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPIN
PTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLF
FIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNW
NGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLM
KHLEES

3D structure

• PDB: 9ayh Structural basis for human Ca v 3.2 inhibition by selective antagonists.
• Chain: A
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	A1AHH	A	L377 F408 N412 F1007 L1547 F1550 F1756 F1802 S1805 Q1848 L1851	L246 F277 N281 F500 L776 F779 F946 F992 S995 Q1038 L1041
BS02	CA	A	E378 E974 D1504	E247 E467 D733
BS03	LPE	A	F393 I400 N1793 G1795 M1796 F1798 F1802	F262 I269 N983 G985 M986 F988 F992
BS04	Y01	A	A1312 L1313 R1315 D1317 F1761 F1794	A544 L545 R547 D549 F951 F984
BS05	JL3	A	F241 G365 W368 I369 S989 W990	F138 G234 W237 I238 S482 W483
BS06	Y01	A	N363 I364 M1636	N232 I233 M826
BS07	JL3	A	S986 T987 S988	S479 T480 S481
BS08	JL3	A	T885 N1528	T387 N757
BS09	Y01	A	L808 V812 Y814	L315 V319 Y321
BS10	Y01	A	G1491 M1495 P1833 V1841	G720 M724 P1023 V1031

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005245 voltage-gated calcium channel activity
• GO:0005261 monoatomic cation channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0005891 voltage-gated calcium channel complex
• GO:0016020 membrane

External links

• PDB: RCSB:9ayh, PDBe:9ayh, PDBj:9ayh
• PDBsum: 9ayh
• PubMed: 38605177
• UniProt: O95180|CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H (Gene Name=CACNA1H)