Structure of PDB 9ayg Chain A

Receptor sequence

>9aygA (length=1055) Species: 9606 (Homo sapiens)

LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA
FFAVEMVIKMVALGLDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRV
LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA
GLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCS
HIPGRRINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWV
DIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETRIVDSK
YFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLK
LLACGPLGYIRNPYNIFDGIIVVISVWEIVGQSVLRTFRLLRVLKLVRFL
PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSPDRKNF
DSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLF
NLLVAILVEGFQRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDID
PGSTERVFLSVSNYIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDG
LLVLVSLVDIVVAMAGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVET
LISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNISTKAQ
CRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQ
PVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHSPTRRSIH
SLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFV
FEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINP
TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFF
IYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWN
GIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMK
HLEES

3D structure

• PDB: 9ayg Structural basis for human Ca v 3.2 inhibition by selective antagonists.
• Chain: A
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	E378 D1504	E247 D732
BS02	LPE	A	F393 I400 M1757 M1796 F1798 L1799 F1802	F262 I269 M946 M985 F987 L988 F991
BS03	Y01	A	A1312 R1315	A543 R546
BS04	JL3	A	F238 F241 G365 Y366 W368 I369 S989 W990	F135 F138 G234 Y235 W237 I238 S482 W483
BS05	Y01	A	F242 N363 I364 H1638	F139 N232 I233 H827
BS06	JL3	A	S986 S988 W990 A991	S479 S481 W483 A484
BS07	JL3	A	S1501 V1546 Q1848 F1849	S729 V774 Q1037 F1038
BS08	JL3	A	T885 N1528 M1531	T387 N756 M759
BS09	Y01	A	Y814 N1489 L1490 G1491	Y321 N717 L718 G719
BS10	Y01	A	G1491 Q1492 M1495 P1837	G719 Q720 M723 P1026

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005245 voltage-gated calcium channel activity
• GO:0005261 monoatomic cation channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0005891 voltage-gated calcium channel complex
• GO:0016020 membrane

External links

• PDB: RCSB:9ayg, PDBe:9ayg, PDBj:9ayg
• PDBsum: 9ayg
• PubMed: 38605177
• UniProt: O95180|CAC1H_HUMAN Voltage-dependent T-type calcium channel subunit alpha-1H (Gene Name=CACNA1H)