Structure of PDB 9ay7 Chain A

Receptor sequence
>9ay7A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
EIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVDPTPEQFQAFRNE
VAVLRKTRHVNILLFMGYMTLAIVTQWCEGSSLYKHLHVQETKFQMFQLI
DIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSQV
EQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHIN
NRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQI
LSSIELLQHS
3D structure
PDB9ay7 The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers.
ChainA
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A I355 G356 G358 S359 F360 V363 K375 W423 C424 K470 N473 F475 D486 I13 G14 G16 S17 F18 V21 K33 W77 C78 K124 N127 F129 D140
BS02 MG A N473 D486 N127 D140
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:9ay7, PDBe:9ay7, PDBj:9ay7
PDBsum9ay7
PubMed38588399
UniProtP04049|RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase (Gene Name=RAF1)

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