Structure of PDB 9avu Chain A

Receptor sequence
>9avuA (length=399) Species: 9913 (Bos taurus) [Search protein sequence]
SEHETRLVAKLFEDYNSVVRPVEDHRQAVEVTVGLQLIQLINVDEVNQIV
TTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDF
AIVKFTKVLLDYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWT
YDGSVVVINPESDQPDLSNFMESGEWVIKESRGWKHWVFYACCPSTPYLD
ITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVL
LSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHH
RSPSTHVMPEWVRKVFIDTIPNIMFFSTMIKHPEVKSAIEGIKYIAETMK
SDQESNNAAEEWKYVAMVMDHILLAVFMLVCIIGTLAVFAGRLIELNQQ
3D structure
PDB9avu Structural switch in acetylcholine receptors in developing muscle
ChainA
Resolution2.45 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN A H206 W207 H186 W187
BS02 ACH A Y113 W169 Y218 Y93 W149 Y198
Gene Ontology
Molecular Function
GO:0015464 acetylcholine receptor activity
GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity
GO:0042166 acetylcholine binding
GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process
GO:0003009 skeletal muscle contraction
GO:0007271 synaptic transmission, cholinergic
GO:0007274 neuromuscular synaptic transmission
GO:0007528 neuromuscular junction development
GO:0019228 neuronal action potential
GO:0034220 monoatomic ion transmembrane transport
GO:0035094 response to nicotine
GO:0042391 regulation of membrane potential
GO:0046716 muscle cell cellular homeostasis
GO:0048630 skeletal muscle tissue growth
GO:0050881 musculoskeletal movement
GO:0050905 neuromuscular process
GO:0051899 membrane depolarization
GO:0060078 regulation of postsynaptic membrane potential
GO:0060079 excitatory postsynaptic potential
GO:0070050 neuron cellular homeostasis
GO:0095500 acetylcholine receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0009986 cell surface
GO:0016020 membrane
GO:0031594 neuromuscular junction
GO:0043005 neuron projection
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0099634 postsynaptic specialization membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:9avu, PDBe:9avu, PDBj:9avu
PDBsum9avu
PubMed39085615
UniProtP02709|ACHA_BOVIN Acetylcholine receptor subunit alpha (Gene Name=CHRNA1)

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