Structure of PDB 9atd Chain A

Receptor sequence
>9atdA (length=303) Species: 1335626 (Middle East respiratory syndrome-related coronavirus) [Search protein sequence]
HHSGLVKMSHPSGDVEACMVQVTCGSMTLNGLWLDNTVWCPRHVMCPADQ
LSDPNYDALLISMTNHSFSVQKHIANLRVVGHAMQGTLLKLTVDVANPST
PAYTFTTVKPGAAFSVLACYNGRPTGTFTVVMRPNYTIKGSFLCGSCGSV
GYTKEGSVINFCYMHQMELANGTHTGSAFDGTMYGAFMDKQVHQVQLTDK
YCSVNVVAWLYAAILNGCAWFVKPNRTSVVSFNEWALANQFTEFVGTQSV
DMLAVKTGVAIEQLLYAIQQLYTGFQGKQILGSTMLEDEFTPEDVNMQIM
GVV
3D structure
PDB9atd Structure-Guided Design of Potent Coronavirus Inhibitors with a 2-Pyrrolidone Scaffold: Biochemical, Crystallographic, and Virological Studies.
ChainA
Resolution1.8 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1AGL A F143 G146 C148 H166 Q167 M168 E169 A171 Q192 V193 H194 F142 G145 C147 H165 Q166 M167 E168 A170 Q191 V192 H193
BS02 A1AGK A H41 F143 C148 H166 Q167 M168 E169 A171 Q192 V193 H43 F142 C147 H165 Q166 M167 E168 A170 Q191 V192
External links
PDB RCSB:9atd, PDBe:9atd, PDBj:9atd
PDBsum9atd
PubMed38953866
UniProtK9N638|R1A_MERS1 Replicase polyprotein 1a (Gene Name=1a)

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