Structure of PDB 9at2 Chain A

Receptor sequence

>9at2A (length=346) Species: 9606 (Homo sapiens) [Search protein sequence]

GLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILW
ELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTAL
DFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEE
NELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEF
IRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRA
LQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGS
SGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLEH

3D structure

PDB

9at2 Structural Insights into Protein-Inhibitor Interactions in Human Tryptophan Dioxygenase.

Chain

Resolution

2.25 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEM	A	F72 H76 Y79 S151 G152 F153 F158 R159 Y175 H328 M331 V332 Y350 L351	F34 H38 Y41 S113 G114 F115 F120 R121 Y137 H290 M293 V294 Y305 L306
BS02	ZIQ	A	R103 E105 W208 R211 P213 F304 P307	R65 E67 W170 R173 P175 F266 P269
BS03	A1AF5	A	F72 H76 R144 S148 P149 A150	F34 H38 R106 S110 P111 A112
BS04	A1AF5	A	Y42 Y45	Y4 Y7

External links

PDB	RCSB:9at2, PDBe:9at2, PDBj:9at2
PDBsum	9at2
PubMed	39106326
UniProt	P48775\|T23O_HUMAN Tryptophan 2,3-dioxygenase (Gene Name=TDO2)

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