Structure of PDB 8zyq Chain A

Receptor sequence

>8zyqA (length=166) Species: 9606 (Homo sapiens) [Search protein sequence]

KAVWDWLILLLVIYTAVFTPYSAAFLLKLIGLLKTARLLRLVRVARKLDR
YSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHRIGWLHNLGDQIG
KPYGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGS
LMYASIFGNVSAIIQR

3D structure

PDB

8zyq Improved higher resolution Cryo-EM structures reveal the binding modes of hERG Channel Inhibitors

Chain

Resolution

3.18 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	1II	A	L622 S624 S649 Y652	L123 S125 S150 Y153

External links

PDB	RCSB:8zyq, PDBe:8zyq, PDBj:8zyq
PDBsum	8zyq
PubMed
UniProt	Q12809\|KCNH2_HUMAN Potassium voltage-gated channel subfamily H member 2 (Gene Name=KCNH2)

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