Structure of PDB 8zul Chain A

Receptor sequence
>8zulA (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
HQLQPRRVSFRGLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRS
KEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEE
GGILYLQTELCGPSLQQHCEAWASLPEAQVWGYLRDTLLALAHLHSQGLV
HLDVKPANIFLGPRGRCKLGDFGLLVELGAGEVQEGDPRYMAPELLQGSY
GTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELR
SVLVMMLEPDPKLRATAEALLALPVLRQ
3D structure
PDB8zul Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1 -Amplified Breast Cancer.
ChainA
Resolution1.80026 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1D84 A Y121 V124 A137 K139 H161 T187 L189 C190 N238 F240 D251 Y42 V45 A58 K60 H82 T108 L110 C111 N158 F160 D171
External links
PDB RCSB:8zul, PDBe:8zul, PDBj:8zul
PDBsum8zul
PubMed39163619
UniProtQ99640|PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Gene Name=PKMYT1)

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