Structure of PDB 8zud Chain A

Receptor sequence
>8zudA (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
HQLQPRRVSFRGETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKV
RSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAW
EEGGILYLQTELCGPSLQQHCEAWASLPEAQVWGYLRDTLLALAHLHSQG
LVHLDVKPANIFLGPRGRCKLGDFGLLVELGAGEVQEGDPRYMAPELLQG
SYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSE
LRSVLVMMLEPDPKLRATAEALLALPVLRQ
3D structure
PDB8zud Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1 -Amplified Breast Cancer.
ChainA
Resolution1.5051 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1D82 A L116 V124 A137 K139 T187 L189 C190 F240 D251 L39 V47 A60 K62 T110 L112 C113 F162 D173
External links
PDB RCSB:8zud, PDBe:8zud, PDBj:8zud
PDBsum8zud
PubMed39163619
UniProtQ99640|PMYT1_HUMAN Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Gene Name=PKMYT1)

[Back to BioLiP]