Structure of PDB 8zp2 Chain A

Receptor sequence
>8zp2A (length=555) Species: 9606 (Homo sapiens) [Search protein sequence]
QPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLI
IAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYN
VIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLKYSKYKFTPAAE
FYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKV
VWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAA
TQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIF
SILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVML
LALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCIT
KGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFR
PGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIA
LSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQ
HWLAI
3D structure
PDB8zp2 Mechanistic insights of substrate transport and inhibitor binding revealed by high-resolution structures of human norepinephrine transporter.
ChainA
Resolution2.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1LX4 A F72 A73 V148 Y151 Y152 G320 F323 S419 G423 A477 F19 A20 V95 Y98 Y99 G258 F261 S357 G361 A415
External links
PDB RCSB:8zp2, PDBe:8zp2, PDBj:8zp2
PDBsum8zp2
PubMed39223283
UniProtP23975|SC6A2_HUMAN Sodium-dependent noradrenaline transporter (Gene Name=SLC6A2)

[Back to BioLiP]