Structure of PDB 8zft Chain A

Receptor sequence
>8zftA (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGSPFVIYDMNSLMMGEDK
IKFEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGV
HEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAV
KFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLK
LNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEI
YKD
3D structure
PDB8zft Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma.
ChainA
Resolution3.2 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EEY A F282 C285 R288 S289 I326 L330 M364 F60 C63 R66 S67 I104 L108 M142
BS02 3JX A L228 F264 I281 G284 F287 R288 L333 I341 S342 E343 L22 F53 I59 G62 F65 R66 L111 I119 S120 E121
External links
PDB RCSB:8zft, PDBe:8zft, PDBj:8zft
PDBsum8zft
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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