Structure of PDB 8zfs Chain A

Receptor sequence
>8zfsA (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKFKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVT
LLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEP
KFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQA
LELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLH
PLLQEIYKD
3D structure
PDB8zfs Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma.
ChainA
Resolution2.56 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EEY A F282 C285 Q286 S289 F363 M364 H449 Y473 F66 C69 Q70 S73 F147 M148 H233 Y257
BS02 241 A C285 R288 S289 A292 I326 M329 L330 I341 S342 C69 R72 S73 A76 I110 M113 L114 I125 S126
External links
PDB RCSB:8zfs, PDBe:8zfs, PDBj:8zfs
PDBsum8zfs
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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