Structure of PDB 8zfq Chain A

Receptor sequence
>8zfqA (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKFKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVT
LLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEP
KFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQA
LELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLH
PLLQEIYKD
3D structure
PDB8zfq Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma.
ChainA
Resolution2.49 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EEY A F282 C285 R288 S289 L330 F363 H449 Y473 F66 C69 R72 S73 L114 F147 H233 Y257
BS02 PLB A F264 I281 G284 C285 R288 L330 V339 I341 S342 M364 F58 I65 G68 C69 R72 L114 V123 I125 S126 M148
External links
PDB RCSB:8zfq, PDBe:8zfq, PDBj:8zfq
PDBsum8zfq
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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