Structure of PDB 8zfp Chain A

Receptor sequence
>8zfpA (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKFEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTL
LKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPK
FEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQAL
ELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHP
LLQEIYK
3D structure
PDB8zfp Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma.
ChainA
Resolution2.48 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GW9 A I281 F282 C285 F360 F363 M364 H449 L453 I64 F65 C68 F143 F146 M147 H232 L236
BS02 241 A G284 C285 R288 S289 A292 I326 Y327 M329 L330 L333 I341 S342 G67 C68 R71 S72 A75 I109 Y110 M112 L113 L116 I124 S125
External links
PDB RCSB:8zfp, PDBe:8zfp, PDBj:8zfp
PDBsum8zfp
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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