Structure of PDB 8z9r Chain A

Receptor sequence

>8z9rA (length=621) Species: 126796 (Thogoto virus (isolate SiAr 126)) [Search protein sequence]

TDRPDHIDSRVWELSETQEDWITQVHGHVRRVVECWKYTICCLISNMHTH
RGAPQYDVFKWQDRSTIEWICSKKKVQYPERDTPDLYDNERAVAYKVLLV
SDLSDHSPTSGIYHDLAFNLEGEAEESCALVLRGSQLQDIKGFLCRALEW
VVSNNLTQEVVETISGEAKLQFSVGTTFRTLLKRDTDWDVIPTPRVEPNV
PRIEGRRWTQMKKLPLLKEKEGPPSPWRALLLGADSEYIVCPPGTDQEAI
SWIHSQSEIECIRESKSTPASVITCLTSSLQSFAEGNPVRSRIHEDIIAF
GINKKQEKKQSASSSASGEWKRAEYQVEEMSLPPWVEEEMVLLRSDQEDN
WIELEKNAIYTEVDGVAEGLVDKYIEIVGRTKVASVIEKWQIAATRTFSQ
LHTDRSRITACPIITRDPSGNCQFWGMVLLGPHHVKRDTDNAPLLIAEIM
GEDTEEKYPKHSVFSLKVEEKQFLLSLKITSFSRNKLYTFSNIRRVLIQP
ASIYSQVVLSRAAENNSLNLEVNPEIQLYLEGAQRGMTLYQWVRMILCLE
FLMAIYNNPQMEGFLANMRRLHMSRHAMMERRQVFLPFGSRPEDKVNECI
INNPIVAYLAKGWNSMPNVYY

3D structure

PDB

8z9r Cryo-EM structures of Thogoto virus polymerase reveal unique RNA transcription and replication mechanisms among orthomyxoviruses

Chain

Resolution

2.58 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	S268 G302 N304 K306 K309 Y326 V328 H435 N442 K461 K479 I480 S482	S267 G301 N303 K305 K308 Y325 V327 H434 N441 K460 K478 I479 S481
BS02	rna	A	D247 D350 W352 I353 E354 E389 Q392 T396 R397 T416 R417 D418 R495	D246 D349 W351 I352 E353 E388 Q391 T395 R396 T415 R416 D417 R494
BS03	rna	A	R438 T440	R437 T439

Gene Ontology

	Cellular Component
GO:0042025	host cell nucleus
GO:0044423	virion component

View graph for
Cellular Component

External links

PDB	RCSB:8z9r, PDBe:8z9r, PDBj:8z9r
PDBsum	8z9r
PubMed	38816392
UniProt	P27194\|PA_THOGV Polymerase acidic protein (Gene Name=Segment)

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