Structure of PDB 8z9h Chain A

Receptor sequence

>8z9hA (length=621) Species: 126796 (Thogoto virus (isolate SiAr 126))

TDRPDHIDSRVWELSETQEDWITQVHGHVRRVVECWKYTICCLISNMHTH
RGAPQYDVFKWQDRSTIEWICSKKKVQYPERDTPDLYDNERAVAYKVLLV
SDLSDHSPTSGIYHDLAFNLEGEAEESCALVLRGSQLQDIKGFLCRALEW
VVSNNLTQEVVETISGEAKLQFSVGTTFRTLLKRDTDWDVIPTPRVEPNV
PRIEGRRWTQMKKLPLLKEKEGPPSPWRALLLGADSEYIVCPPGTDQEAI
SWIHSQSEIECIRESKSTPASVITCLTSSLQSFAEGNPVRSRIHEDIIAF
GINKKQEKKQSASSSASGEWKRAEYQVEEMSLPPWVEEEMVLLRSDQEDN
WIELEKNAIYTEVDGVAEGLVDKYIEIVGRTKVASVIEKWQIAATRTFSQ
LHTDRSRITACPIITRDPSGNCQFWGMVLLGPHHVKRDTDNAPLLIAEIM
GEDTEEKYPKHSVFSLKVEEKQFLLSLKITSFSRNKLYTFSNIRRVLIQP
ASIYSQVVLSRAAENNSLNLEVNPEIQLYLEGAQRGMTLYQWVRMILCLE
FLMAIYNNPQMEGFLANMRRLHMSRHAMMERRQVFLPFGSRPEDKVNECI
INNPIVAYLAKGWNSMPNVYY

3D structure

• PDB: 8z9h Cryo-EM structures of Thogoto virus polymerase reveal unique RNA transcription and replication mechanisms among orthomyxoviruses
• Chain: A
• Resolution: 2.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	R229 S268 G302 N304 K305 K306 K309 Y326 V328 H435 N442 K461 K479 I480 T481 S482 P560	R228 S267 G301 N303 K304 K305 K308 Y325 V327 H434 N441 K460 K478 I479 T480 S481 P559
BS02	rna	A	D247 Q248 G287 D350 W352 E354 E389 Q392 R397 R417 D418 P419 Q424 R495	D246 Q247 G286 D349 W351 E353 E388 Q391 R396 R416 D417 P418 Q423 R494
BS03	rna	A	R438 T440	R437 T439

Gene Ontology

Cellular Component

• GO:0042025 host cell nucleus
• GO:0044423 virion component

External links

• PDB: RCSB:8z9h, PDBe:8z9h, PDBj:8z9h
• PDBsum: 8z9h
• PubMed: 38816392
• UniProt: P27194|PA_THOGV Polymerase acidic protein (Gene Name=Segment)