Structure of PDB 8z97 Chain A

Receptor sequence

>8z97A (length=621) Species: 126796 (Thogoto virus (isolate SiAr 126)) [Search protein sequence]

TDRPDHIDSRVWELSETQEDWITQVHGHVRRVVECWKYTICCLISNMHTH
RGAPQYDVFKWQDRSTIEWICSKKKVQYPERDTPDLYDNERAVAYKVLLV
SDLSDHSPTSGIYHDLAFNLEGEAEESCALVLRGSQLQDIKGFLCRALEW
VVSNNLTQEVVETISGEAKLQFSVGTTFRTLLKRDTDWDVIPTPRVEPNV
PRIEGRRWTQMKKLPLLKEKEGPPSPWRALLLGADSEYIVCPPGTDQEAI
SWIHSQSEIECIRESKSTPASVITCLTSSLQSFAEGNPVRSRIHEDIIAF
GINKKQEKKQSASSSASGEWKRAEYQVEEMSLPPWVEEEMVLLRSDQEDN
WIELEKNAIYTEVDGVAEGLVDKYIEIVGRTKVASVIEKWQIAATRTFSQ
LHTDRSRITACPIITRDPSGNCQFWGMVLLGPHHVKRDTDNAPLLIAEIM
GEDTEEKYPKHSVFSLKVEEKQFLLSLKITSFSRNKLYTFSNIRRVLIQP
ASIYSQVVLSRAAENNSLNLEVNPEIQLYLEGAQRGMTLYQWVRMILCLE
FLMAIYNNPQMEGFLANMRRLHMSRHAMMERRQVFLPFGSRPEDKVNECI
INNPIVAYLAKGWNSMPNVYY

3D structure

PDB

8z97 Cryo-EM structures of Thogoto virus polymerase reveal unique RNA transcription and replication mechanisms among orthomyxoviruses

Chain

Resolution

2.65 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	R229 S268 G302 N304 K305 K306 K309 Y326 V328 H435 N442 K461 K479 I480 S482 P560	R228 S267 G301 N303 K304 K305 K308 Y325 V327 H434 N441 K460 K478 I479 S481 P559
BS02	rna	A	D247 Q248 G287 D350 W352 E389 Q392 I393 R397 R417 D418 R495	D246 Q247 G286 D349 W351 E388 Q391 I392 R396 R416 D417 R494
BS03	rna	A	R438 T440	R437 T439

Gene Ontology

	Cellular Component
GO:0042025	host cell nucleus
GO:0044423	virion component

View graph for
Cellular Component

External links

PDB	RCSB:8z97, PDBe:8z97, PDBj:8z97
PDBsum	8z97
PubMed	38816392
UniProt	P27194\|PA_THOGV Polymerase acidic protein (Gene Name=Segment)

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