Structure of PDB 8yxm Chain A

Receptor sequence
>8yxmA (length=1368) Species: 2560602 (Mumps orthorubulavirus) [Search protein sequence]
LNEILLPEVHLNSPIVRYKLFYYILHGQLPNDLEPDDLGPLANQNWKAIR
AEESQVHARLKQIRVELIARIPSLRWTRSQREIAILIWPRILPILQAYDL
RQSMQLPTVWEKLTQSTVNLISDGLERVVLHISNQLTGKPNLFTRSRAYS
IPSTRELSQIWFNNEWSGSVKTWLMIKYRMRQLITNQKTGELTDLVTIVD
TRSTLCIITPELVALYSSEHKALTYLTFEMVLMVTDMLEGRLNVSSLCTA
SHYLSPLKKRIEVLLTLVDDLALLMGDKVYGIVSSLESFVYAQLQYGDPV
IDIKGTFYGFICNEILDLLTEDNIFTEEEANKVLLDLTSQFDNLSPDLTA
ELLCIMRLWGHPTLTASQAASKVRESMCAPKVLDFQTIMKTLAFFHAILI
NGYRRSHNGIWPPTTLHGNAPKSLIEMRHDNSELKYEYVLKNWKSISMLR
IHKCFDASPDEDLSIFMKDKAISCPRQDWMGVFRRSLIKQRYRDANRPLP
QPFNRRLLLNFLEDDRFDPIKELEYVTSGEYLRDPEFCASYSLKEKEIKA
TGRIFAKMTKRMRSCQVIAESLLANHAGKLMRENGVVLDQLKLTKSLLTM
NQIGIISEHGFEIAACFLTTDLTKYCLNWRYQVIIPFARTLNSMYGIPHL
FEWIHLRLMRSTLYVGDPFNPPSDPTQLDLDTALNDDIFIVSPRGGIEGL
CQKLWTMISISTIILSATEANTRVMSMVQGDNQAIAITTRVVRSLSHSEK
KEQAYKASKLFFERLRANNHGIGHHLKEQETILSSDFFIYSKRVFYKGRI
LTQALKNVSKMCLTADILGDCSQASCSNLATTVMRLTENGVEKDLCYFLN
AFMTIRQLCYDLVFPQTKSLSQDITNAYLNHPILISRLCLLPSQLGGLNF
LSCSRLFNRNIGDPLVSAIADVKRLIKAGCLDIWVLYNILGRRPGKGKWS
TLAADPYTLNIDYLVPSTTFLKKHAQYTLMERSVNPMLRGVFSENAAEEE
EELAQYLLDREVVMPRVAHVILAQSSCGRRKQIQGYLDSTRTIIRYSLEV
RPLSAKKLNTVIEYNLLYLSYNLEIIEKPNIVQPFLNAINVDTCSIDIAR
SLRKLSWATLLNGRPIEGLETPDPIELVHGCLIIGSDECEHCSSGDDKFT
WFFLPKGIRLDDDPASNPPIRVPYIGSKTDVASMAYIKGASVSLKSALRL
AGVYIWAFGDTEESWQDAYELASTRVNLTLEQLQSLTPLPTSANLVHRKF
TPASSYAFSSFVHISNDCQILTDSNLIYQQVMITGLALIETWNNPPINFS
VYETTLHLHTGSSCCIRPVESCVVNPPLLPVPLINVPQMNKFVYDPEPLS
LLEMEKIEDIAYQTRIGG
3D structure
PDB8yxm Structures of the mumps virus polymerase complex via cryo-electron microscopy.
ChainA
Resolution2.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.375: NNS virus cap methyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.88: GDP polyribonucleotidyltransferase.
3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1187 C1190 H1372 H1374 C1139 C1142 H1307 H1309
BS02 ZN A C1142 C1379 C1380 C1094 C1314 C1315
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
GO:0016787 hydrolase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006370 7-methylguanosine mRNA capping
GO:0032259 methylation
GO:0106005 RNA 5'-cap (guanine-N7)-methylation
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8yxm, PDBe:8yxm, PDBj:8yxm
PDBsum8yxm
PubMed38760379
UniProtC0JJA4

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