Structure of PDB 8yte Chain A

Receptor sequence
>8yteA (length=98) Species: 9606 (Homo sapiens) [Search protein sequence]
VSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTE
FLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
3D structure
PDB8yte Discovery and Hit to Lead Optimization of Macrocyclic Peptides as Novel Tropomyosin Receptor Kinase A Antagonists.
ChainA
Resolution2.26 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A A310 P311 S312 L313 E324 T325 S326 F329 T330 F332 E334 A29 P30 S31 L32 E43 T44 S45 F48 T49 F51 E53
External links
PDB RCSB:8yte, PDBe:8yte, PDBj:8yte
PDBsum8yte
PubMed38950284
UniProtP04629|NTRK1_HUMAN High affinity nerve growth factor receptor (Gene Name=NTRK1)

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