Structure of PDB 8ytd Chain A

Receptor sequence
>8ytdA (length=102) Species: 9606 (Homo sapiens) [Search protein sequence]
NVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFT
EFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMD
NP
3D structure
PDB8ytd Discovery and Hit to Lead Optimization of Macrocyclic Peptides as Novel Tropomyosin Receptor Kinase A Antagonists.
ChainA
Resolution2.34 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A A310 P311 S312 L313 E324 S326 F329 T330 F332 L333 E334 R342 A30 P31 S32 L33 E44 S46 F49 T50 F52 L53 E54 R62
BS02 peptide A V321 L322 N323 T325 F327 I328 Q350 V354 N355 V41 L42 N43 T45 F47 I48 Q70 V74 N75
External links
PDB RCSB:8ytd, PDBe:8ytd, PDBj:8ytd
PDBsum8ytd
PubMed38950284
UniProtP04629|NTRK1_HUMAN High affinity nerve growth factor receptor (Gene Name=NTRK1)

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