Structure of PDB 8yki Chain A

Receptor sequence
>8ykiA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
ELPEDPRWELPRDRLVLGKPLGEFGQVVLAEAIGLDKDKPNRVTKVAVKM
LKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS
KGNLREYLQARRPEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV
LVTEDNVMKIADFGLALPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFT
LGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRP
TFKQLVEDLDRIVALTS
3D structure
PDB8yki Antitumor Activity of Tasurgratinib as an Orally Available FGFR1-3 Inhibitor in Cholangiocarcinoma Models With FGFR2-fusion.
ChainA
Resolution2.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1LY1 A L484 A512 K514 E531 M535 V561 A564 G567 L630 L21 A47 K49 E66 M70 V96 A99 G102 L151
External links
PDB RCSB:8yki, PDBe:8yki, PDBj:8yki
PDBsum8yki
PubMed38821585
UniProtP11362|FGFR1_HUMAN Fibroblast growth factor receptor 1 (Gene Name=FGFR1)

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