Structure of PDB 8yk5 Chain A

Receptor sequence
>8yk5A (length=664) Species: 193460 (Streptomyces sanglieri) [Search protein sequence]
DGLGAIKHVVILMQENRSFDHYFGTLRGVRGFGDRNAVELPSGKPVFEQP
AALGTSVLPFPVRDAAETQKKDLQYIGALDHSWSGGGKAWAGGWMNGWVS
AKTAATMAYYDRRDIPLHYELADTFTVCDAYHSSIHTSTSPNRNHLWSGK
TGNEPNGKRAVGNDAYNEGTHPGYDWGTYAERLEKAGRSWRTYTEWENFT
DNQIEFFATFKAVARKALAKTGGHTFMESFYAAVRDADATERERLFGLLE
EGVATLDKTERSLFERALRRVETGTLADEFAKDVAAGTLPEVSYLVPSAV
DSEHPSVSSPIHSATIVYKVLDALGKHPDVWRHTAVFINYDENDGFFDHV
PPPVASPEVTEEQWEGKPTGLGMRVPMLVVSPWTIGGYVCSEVFDHTSVV
RFLERWTGVAEPNISDWRRTVTGDLTSAFDFSHARRRPEVEQPGAIPPFS
GRWSPKPPAVQHMPVQEPGARPARALPYQPDAQATVEDGAVRVDLSNTGR
SSAHFALYPYAGEFPVPQHRDVKGTARWTVPVTGAAYRFTVTGPNGFRRE
FAGPAKDGASAGAEVASRVDARERDLHLTLRNTGRTTLTFTVRPLGYVDE
ADLRDWTRTVKVKPGRSRTVVHSAADAHGWYDLDVTVDGDDAFRRRLMGH
IENGRASVSGHHHH
3D structure
PDB8yk5 Structure of a phosphodiesterase from Streptomyces sanglieri with a novel C-terminal domain.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.3: phospholipase C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E15 N16 T139 D341 E342 E15 N16 T139 D341 E342
BS02 GOL A E15 N16 H81 T139 N163 H304 E15 N16 H81 T139 N163 H304
Gene Ontology
Molecular Function
GO:0004629 phospholipase C activity
GO:0016298 lipase activity
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0034480 phosphatidylcholine phospholipase C activity
GO:0042578 phosphoric ester hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0016042 lipid catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8yk5, PDBe:8yk5, PDBj:8yk5
PDBsum8yk5
PubMed38503170
UniProtA0A077KPD5

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