Structure of PDB 8ygy Chain A

Receptor sequence
>8ygyA (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLW
LGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLL
RLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQC
VDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVL
QGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS
3D structure
PDB8ygy Structure of the KLK1 from Biortus.
ChainA
Resolution2.401 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.35: tissue kallikrein.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUC A H109 Q112 E115 H85 Q88 E91
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0003073 regulation of systemic arterial blood pressure
GO:0006508 proteolysis
GO:0031638 zymogen activation
Cellular Component
GO:0005634 nucleus
GO:0030141 secretory granule
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ygy, PDBe:8ygy, PDBj:8ygy
PDBsum8ygy
PubMed
UniProtP06870|KLK1_HUMAN Kallikrein-1 (Gene Name=KLK1)

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